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免疫功能正常患者的特发性脑桥唾液链球菌脓肿:通过病例说明和文献综述获得的治疗经验

Idiopathic pontine Streptococcus salivarius abscess in an immunocompetent patient: management lessons through case illustration and literature review.

作者信息

Mandapat Aimee Luna, Eddleman Christopher S, Bissonnette Mei Lin, Batjer H Hunt, Zembower Teresa R

机构信息

Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue Suite 900, Chicago, Illinois 60611, USA.

出版信息

Scand J Infect Dis. 2011 Dec;43(11-12):837-47. doi: 10.3109/00365548.2011.593544. Epub 2011 Jul 14.

Abstract

A 55-y-old woman with no previous medical history presented with a 3-day history of progressive headache, nausea, emesis, right-sided facial numbness, and right-sided extremity weakness. Serial magnetic resonance imaging demonstrated rapid enlargement of a left-sided ring-enhancing dorsal pontine lesion with an exophytic portion, raising concern for an abscess. A stereotactically guided left-sided retrosigmoid craniotomy for abscess incision and decompression was performed given the rapid progression of her neurological deficits. Streptococcus salivarius was isolated from the intra-operative samples. After an extensive evaluation, no source for the S. salivarius was identified. Solitary brainstem abscesses are uncommon intracranial infections with high morbidity and mortality. Patients can present with non-specific symptoms and often have no previous medical history. Since 1974, 40 patients with solitary brainstem abscess have survived to hospital discharge. We outline management strategies for solitary brainstem abscess based on a literature review of survivors.

摘要

一名55岁无既往病史的女性,出现进行性头痛、恶心、呕吐、右侧面部麻木和右侧肢体无力3天。系列磁共振成像显示左侧脑桥背侧环形强化病变迅速增大,并有一个外生性部分,令人担心是脓肿。鉴于其神经功能缺损进展迅速,遂行立体定向引导下左侧乙状窦后开颅术以进行脓肿切开减压。术中样本分离出唾液链球菌。经过广泛评估,未发现唾液链球菌的来源。孤立性脑干脓肿是罕见的颅内感染,发病率和死亡率高。患者可表现为非特异性症状,且通常无既往病史。自1974年以来,40例孤立性脑干脓肿患者存活至出院。我们基于对幸存者的文献综述概述了孤立性脑干脓肿的管理策略。

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