Stip Emmanuel, Abdel-Baki Amal, Bloom David, Grignon Sylvain, Roy Marc-André
Département de psychiatrie de l'Université de Montréal.
Can J Psychiatry. 2011 Jun;56(6):367-76. doi: 10.1177/070674371105600608.
To present points of agreement and disagreement about antipsychotics. Since the appearance of 2nd generation long-acting antipsychotics (LAA), and given the high frequency of noncompliance with antipsychotics in psychotic disorders, LAAs have attracted more interest in psychiatric literature. However,their use is suboptimal, globally, and is also subject to significant national disparities. ln this context,the Association des médecins psychiatres du Québec (AMPQ) has asked for a review of the evidence concerning LAA efficiency and tolerance, and has called for consensual c1inical reflection on the benefits and obstacles of prescribing them, as weil as potential solutions, including administrative and judiciary dimensions.
The AMPQ established an expert committee, from 4 Quebec universities, which was responsible for preparing the review paper. The committee intended to appropriately provide c1inicians with the different aspects of LAA use. The committee produced a qualitative and selective review.
Mean LAA prescription rates observed in Canada are around 6% and data to confirm this are scarce. A 15% to 25% rate could be suggested.
The committee has submitted the Quebec long-acting antipsychotic algorithm (QAAPAPLE, derived from the French acronym) as a result of the consensus reached by the 4 university psychiatry departments.
阐述关于抗精神病药物的共识与分歧。自第二代长效抗精神病药物（LAA）出现以来，鉴于精神病性障碍患者中抗精神病药物治疗依从性差的情况很常见，长效抗精神病药物在精神科文献中受到了更多关注。然而，从全球范围来看，它们的使用并不理想，而且在各国之间也存在显著差异。在此背景下，魁北克精神科医生协会（AMPQ）要求对有关长效抗精神病药物有效性和耐受性的证据进行综述，并呼吁就处方使用长效抗精神病药物的益处、障碍以及潜在解决方案（包括行政和司法层面）进行共识性的临床思考。
AMPQ成立了一个由魁北克四所大学的专家组成的委员会，负责撰写综述论文。该委员会旨在为临床医生恰当提供长效抗精神病药物使用的不同方面的信息。委员会进行了定性和选择性的综述。
在加拿大观察到的长效抗精神病药物平均处方率约为6%，但证实这一数据的资料很少。可以推测其处方率在15%至25%之间。
由于四所大学的精神科部门达成了共识，该委员会提交了魁北克长效抗精神病药物算法（QAAPAPLE，源自法语首字母缩写）。
