非甾体抗炎药的作用机制及治疗考量

Mechanisms of action of nonsteroidal anti-inflammatory drugs and therapeutic considerations.

作者信息

Abramson S B

机构信息

Department of Rheumatology, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003.

出版信息

Bull Hosp Jt Dis Orthop Inst. 1990 Fall;50(2):107-15.

PMID:2175657

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) have anti-inflammatory, analgesic, and antipyretic properties. Although most NSAIDs inhibit prostaglandin synthesis, these agents also have important pharmacologic actions unrelated to their effects on prostaglandins. This review examines the evidence for diverse mechanisms of action of NSAIDs and their use in sports injuries.

摘要

非甾体抗炎药（NSAIDs）具有抗炎、镇痛和解热特性。尽管大多数非甾体抗炎药抑制前列腺素合成，但这些药物也具有与其对前列腺素的作用无关的重要药理作用。本综述探讨了非甾体抗炎药作用的多种机制及其在运动损伤中的应用的证据。