嘌呤霉素氨基核苷肾病综合征中的血管紧张素I转换酶活性

Angiotensin I-converting enzyme activity in puromycin aminonucleoside-nephrotic syndrome.

作者信息

Arévalo A E, Ibarra-Rubio M E, Cruz C, Peńa J C, Pedraza-Chaverrí J

机构信息

Departamento de Nefrología y Metabolismo Mineral, Instituto Nacional de la Nutrición Salvador Zubirán, Mexico.

出版信息

Clin Chim Acta. 1990 Nov 5;191(3):175-84. doi: 10.1016/0009-8981(90)90019-o.

DOI:10.1016/0009-8981(90)90019-o

PMID:2175683

Abstract

Puromycin aminonucleoside (PAN)-nephrotic rats have high serum angiotensin I-converting enzyme (ACE) activity. We studied ACE activity in serum, urine, and tissues from PAN-nephrotic rats on days 2, 6, 11, and 16 after PAN injection. Proteinuria and hypoproteinemia were evident on days 6 and 11. Though significantly decreased, proteinuria was still evident on day 16. Serum ACE activity increased on days 2, 6, and 11. Urinary ACE activity became evident on days 6, 11, and 16 and correlated positively with proteinuria, suggesting that the source of urine ACE is the blood serum. ACE activity increased in testis on days 2 and 6, in lungs and aorta on days 6 and 11, in adrenal glands and small intestine on day 11, and in kidney on days 11 and 16. Heart ACE activity decreased on days 2 and 6, and increased on day 16; brain ACE activity decreased on day 6 and increased on day 11. These data implicate that changes in tissue ACE content may contribute to elevate serum ACE in PAN-nephrotic rats.

摘要

嘌呤霉素氨基核苷（PAN）肾病大鼠具有较高的血清血管紧张素I转换酶（ACE）活性。我们研究了PAN注射后第2、6、11和16天PAN肾病大鼠血清、尿液和组织中的ACE活性。蛋白尿和低蛋白血症在第6天和第11天明显。虽然在第16天蛋白尿显著减少，但仍很明显。血清ACE活性在第2、6和11天升高。尿ACE活性在第6、11和16天变得明显，并与蛋白尿呈正相关，提示尿ACE的来源是血清。睾丸ACE活性在第2天和第6天升高，肺和主动脉在第6天和第11天升高，肾上腺和小肠在第11天升高，肾脏在第11天和第16天升高。心脏ACE活性在第2天和第6天降低，在第16天升高；脑ACE活性在第6天降低，在第11天升高。这些数据表明，组织ACE含量的变化可能导致PAN肾病大鼠血清ACE升高。