Division of Hemato-Oncology, Department of Internal Medicine, Chi-Mei Medical Center, Liouying, Tainan, Taiwan.
Kaohsiung J Med Sci. 2011 Jul;27(7):289-91. doi: 10.1016/j.kjms.2010.08.005. Epub 2011 Apr 17.
Nasopharyngeal carcinoma (NPC) is prevalent in Taiwan and is characterized by a high frequency of nodal metastasis. The most common organs with distal metastases are the bones, lungs, and liver, with extremely rare cases to the pericardium. Herein, we report a rare case with NPC who presented with dyspnea and orthopnea. Serial studies, including pericardial biopsy, revealed NPC with pericardial metastasis and pericardial effusion. The tumor cells of both the original and metastatic tumors were positive for Epstein-Barr virus by in situ hybridization. This is the first histologically confirmed case of NPC with pericardial metastasis.
鼻咽癌（NPC）在台湾地区较为常见，其特征是淋巴结转移率较高。远处转移最常见的器官是骨骼、肺部和肝脏，极罕见转移至心包。本文报告 1 例罕见的 NPC 患者，以呼吸困难和端坐呼吸为主要表现。连续的研究，包括心包活检，提示 NPC 合并心包转移和心包积液。原位杂交显示原发和转移肿瘤的肿瘤细胞均为 EBV 阳性。这是首例经组织学证实的 NPC 合并心包转移病例。
