Winkler J, Boner G
Sackler Orvostudományi Egyetem, Tel-Aviv, Beilinson Kórház Nephrologiai Központ, Izrael.
Orv Hetil. 1990 Dec 2;131(48):2649-53.
The rare congenital lactic acidosis is a consequence of enzyme defects. The acquired form is relatively common in critically ill patients. The altered metabolism of pyruvate and the imbalance between lactate production and utilization have a central role in the pathogenesis of this disease. The physiologic compensating mechanisms are generally not sufficient for complete correction of acidosis. In most of the cases the basic disease is the one that should be treated. The correction of the acidosis must be careful, because overtreatment may worsen acidosis, or may cause severe post-treatment alkalosis.
罕见的先天性乳酸性酸中毒是酶缺陷的结果。获得性形式在危重病患者中相对常见。丙酮酸代谢改变以及乳酸生成与利用之间的失衡在该病的发病机制中起核心作用。生理代偿机制通常不足以完全纠正酸中毒。在大多数情况下，应治疗基础疾病。酸中毒的纠正必须谨慎，因为过度治疗可能会使酸中毒恶化，或导致严重的治疗后碱中毒。
