Krasnov M M, Dvali M L, Polunin G S, Ivanov M N, Fedorov A A, Shramko I A
Vestn Oftalmol. 1990 Sep-Oct;106(5):8-12.
Experimental and clinical study of lekozim and collalysine proteolytic enzymes efficacies in extracapsular cataract extraction was carried out. Local application of these agents in irrigation aspiration of the cortical mass from the capsule sac equator not only simplified the technique of the most intricate stage of surgery, but also proved to be a sufficiently effective means of secondary cataract prevention. A follow-up of up to 3 years has shown secondary cataract development in 5 percent of patients after extracapsular cataract extraction administered lekozim, in 10 percent of those administered collalysine, and in 17.5 percent of cases with mechanical vacuum extraction. Lekozim and collalysine may be used in all the cases when extracapsular cataract extraction is possible.
进行了关于lekozim和胶原赖氨酸蛋白水解酶在囊外白内障摘除术中疗效的实验和临床研究。在从囊袋赤道部冲洗吸出皮质物质时局部应用这些药物,不仅简化了手术最复杂阶段的技术,而且被证明是预防继发性白内障的一种足够有效的方法。长达3年的随访显示,接受lekozim治疗的囊外白内障摘除术后患者中有5%发生继发性白内障,接受胶原赖氨酸治疗的患者中有10%发生,而机械真空抽吸病例中有17.5%发生。当有可能进行囊外白内障摘除时,lekozim和胶原赖氨酸可用于所有病例。