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[蛋白水解酶lekozim或kollalizin在眼部烧伤联合治疗中的超声药物透入疗法]

[Phonophoresis of the proteolytic enzymes lekozim or kollalizin in the combined therapy of eye burns].

作者信息

Iakimenko S A, Chalanova R I

出版信息

Oftalmol Zh. 1990(6):321-4.

PMID:1966113
Abstract

A two-stage phonophoresis of proteolytic enzymes of lecozim or collalysine was used in a complex treatment of severe eye burns. The main group of patients consisted of 20 patients (23 eyes) treated by lecozim phonophoresis and 6 patients (6 eyes)--by collalysine phonophoresis. The control group consisted of 23 patients (25 eyes) treated by a complex treatment without phonophoresis of proteolytic enzymes. The comparative analysis of the course of a burn disease in both groups has shown positive influence of enzyme therapy on its dynamics and outcome. In the main group, the arrest of inflammatory signs accomplished earlier (by the 27th-29th day) as compared with the control group (by the 32nd-38th day) as well as epithelialization of corneal defects (by the 27th-30th day and by the 34th-42nd day, respectively); earlier vascularization of the cornea stimulated improvement of the burn process. Of a characteristic feature of the treatment was resolution of corneal opacification that began already after the first stage and continued within the second stage of the treatment. This allowed to achieve higher functional results. In the main group, visual acuity rose in 88.5%, and in the control--in 48% of patients.

摘要

采用两阶段导入乐可齐姆或胶原溶解素蛋白水解酶的超声药物透入疗法对严重眼部烧伤进行综合治疗。主要患者组包括20例患者(23只眼)接受乐可齐姆超声药物透入治疗,以及6例患者(6只眼)接受胶原溶解素超声药物透入治疗。对照组包括23例患者(25只眼),采用不进行蛋白水解酶超声药物透入的综合治疗。两组烧伤疾病病程的对比分析显示,酶疗法对其动态变化和转归有积极影响。在主要患者组中,炎症体征的消退比对照组更早完成(分别在第27 - 29天和第32 - 38天),角膜缺损的上皮化也更早(分别在第27 - 30天和第34 - 42天);角膜更早血管化促进了烧伤过程的改善。该治疗的一个特征是角膜混浊的消退在治疗的第一阶段后就已开始,并在第二阶段持续进行。这使得能够获得更高的功能恢复效果。在主要患者组中,88.5%的患者视力提高,而在对照组中,这一比例为48%。

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