[Morpho-functional changes in the vascular bed in obstructed portal blood flow].

Clinical observations were performed in 104 patients with intrahepatic blockade and 32 patients with subhepatic blockade of portal bloodflow and experimental studies in 24 mongrel dogs with the model of dosed stenosis of the portal vein. It was found that microcirculation bed of hollow organs of the gastrointestinal tract is also involved into the circle of pathological disorders in portal hypertension. Alterations of the microcirculation bed consist in the appearance of destructive lesions of the microvessel walls, disturbance of their permeability and hemodynamics. Undoubtedly, genesis of functional disturbances is based on structural alterations.