Kop'eva T N, Sekamova S M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1990;90(9):13-7.
Thymus excised from 68 patients suffering from juvenile myasthenia was subjected to histological, histochemical and electron microscopy studies. The changes in the thymus involved hyperplastic immune response in the form of lymphoid follicles with the germinal centers and focal plasmocytic infiltration. In myasthenia, the permanent characteristic of the thymus was activation of epithelial cells and Hassal bodies. A direct relationship was discovered between the efficacy of thymectomy and intensity of hyperplasia of the glandular lobules of the thymus. The lobule number of lymphoid follicles with the germinal centers did not affect the results of the surgical treatment of patients suffering from myasthenia.
对68例青少年型重症肌无力患者切除的胸腺进行了组织学、组织化学和电子显微镜研究。胸腺的变化包括以带有生发中心的淋巴滤泡和局灶性浆细胞浸润形式出现的增生性免疫反应。在重症肌无力中，胸腺的一个持久特征是上皮细胞和哈氏小体的激活。发现胸腺切除术的疗效与胸腺腺小叶增生强度之间存在直接关系。带有生发中心的淋巴滤泡的小叶数量不影响重症肌无力患者手术治疗的结果。
