Department of Chemistry, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio, USA.
Dalton Trans. 2011 Aug 28;40(32):8083-5. doi: 10.1039/c1dt10578g. Epub 2011 Jul 15.
A series of four dendrimers end-functionalized with gold(I) has been prepared from alkyne-terminated precursors and (tricyclohexylphosphine)gold(I) azide. Isolated yields range from 84-89%, based on gold. The first-generation dendrimer is cytotoxic toward 3T3 mouse fibroblast cells. Apoptosis ensues within 6 h of treatment with gold(I).
已经从炔基封端的前体和（三环己基膦）金（I）叠氮化物制备了一系列四个末端官能化的金（I）树状大分子。基于金，分离产率范围为 84-89%。第一代树状大分子对 3T3 小鼠成纤维细胞具有细胞毒性。在用金（I）处理 6 小时内，会发生细胞凋亡。
