Pérez Cristina, Navarro Ana, Martínez Eva, Ordóñez Cristina, Del Valle Eva, Tolivia Jorge
Department of Morphology and Cellular Biology, 8ª Planta Facultad de Medicina, University of Oviedo, c/ Julián Clavería s/n, Oviedo, Spain.
Age (Dordr). 2012 Aug;34(4):895-904. doi: 10.1007/s11357-011-9286-5. Epub 2011 Jul 15.
Aging is associated with a reduction in metabolic functions, increased incidence of neurodegenerative diseases, and memory or cognitive dysfunction. With aging, a decrease in plasma estrogen levels, related to loss of gonadal function, occurs in females. Estrogens have neuroprotective effects and estradiol treatment improves some aspects of neuronal homeostasis affected by aging. In other way, recent studies show that apo D can play a neuroprotective role in some neuropathologies and during aging. The possible relation between estradiol treatment and the expression of apo D, during aging in the CNS, was investigated in female rats. Our results confirm an expression of apo D zone-dependent, in relation with aging, and an overexpression of apo D related to ovariectomy and estradiol treatment. This overexpression strengthens the idea that apo D plays a neuroprotective role in the CNS.
衰老与代谢功能减退、神经退行性疾病发病率增加以及记忆或认知功能障碍有关。随着年龄增长，女性会出现与性腺功能丧失相关的血浆雌激素水平下降。雌激素具有神经保护作用，雌二醇治疗可改善受衰老影响的神经元内环境稳定的某些方面。另一方面，最近的研究表明，载脂蛋白D在某些神经病理学和衰老过程中可发挥神经保护作用。我们在雌性大鼠中研究了中枢神经系统衰老过程中雌二醇治疗与载脂蛋白D表达之间的可能关系。我们的结果证实，载脂蛋白D的表达与衰老相关且具有区域依赖性，并且与卵巢切除术和雌二醇治疗相关的载脂蛋白D过表达。这种过表达强化了载脂蛋白D在中枢神经系统中发挥神经保护作用的观点。
