Department of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246 Hamburg, Germany.
Eur Radiol. 2011 Dec;21(12):2626-32. doi: 10.1007/s00330-011-2206-3. Epub 2011 Jul 16.
Different compositions of the extra cellular matrix with changing concentrations of more or less hydrophilic components like proteins may have a major influence on the diffusion phenomena found in gliomas.
24 patients (14 male / 10 female) with histologically confirmed non necrotic glioma underwent preoperative MRI, including magnetisation transfer (MTR), triple echo T2 weighted (T2W) and diffusion weighted (DWI) sequences. Apparent diffusion coefficient (ADC), quantitative T2 and MTR maps were calculated and regions of interest (ROIs) were placed in the tumour centre (TU) and in the contralateral hemisphere (NWM). Informed consent was obtained. The study was approved by the local ethic comity.
Mean values evaluated in the NWM / TU were (± standard deviation); ADC: 0.78 (±0.08) × 10-3 mm2/s / 1.32 (±0.27) × 10-3 mm2/s, T2: 101.66 (±12.00) ms / 252.11 (±104.53) ms, MTR: 0.52 (±0.01) / 0.40 (±0.04). The mean value of each parameter correlated highly significant with the others (p < 0.01).
Our results suggest that macromolecules binding protons in their vicinity are a major determinant of proton diffusivity in brain tumours in addition to other factors such as mechanical barriers like membranes or the size of the extra-cellular space.
细胞外基质的不同组成成分和不同浓度的亲水性成分（如蛋白质）可能对胶质瘤中发现的扩散现象有重大影响。
24 名经组织学证实的非坏死性胶质瘤患者（14 名男性/10 名女性）接受了术前 MRI 检查，包括磁化传递（MTR）、三回波 T2 加权（T2W）和弥散加权（DWI）序列。计算表观扩散系数（ADC）、定量 T2 和 MTR 图，并在肿瘤中心（TU）和对侧半球（NWM）中放置感兴趣区（ROI）。获得知情同意。该研究得到了当地伦理委员会的批准。
在 NWM/TU 中评估的平均值为（±标准差）；ADC：0.78（±0.08）×10-3mm2/s/1.32（±0.27）×10-3mm2/s，T2：101.66（±12.00）ms/252.11（±104.53）ms，MTR：0.52（±0.01）/0.40（±0.04）。每个参数的平均值与其他参数高度相关（p<0.01）。
我们的结果表明，除了其他因素（如膜等机械屏障或细胞外空间的大小）外，邻近质子结合的大分子也是脑肿瘤中质子扩散的主要决定因素。
