Division of Cardiology, Department of Medicine, Alpert Medical School of Brown University and Rhode Island Hospital, Providence, RI, USA.
J Nucl Cardiol. 2011 Oct;18(5):886-92. doi: 10.1007/s12350-011-9405-9. Epub 2011 Jul 15.
Bariatric surgery for management of obesity is being used with increasing frequency. Stress testing with myocardial perfusion imaging is often employed as part of the workup prior to anticipated bariatric surgery. The incidence of clinically significant abnormalities on stress MPI performed for this indication, however, has not been established.
We retrospectively reviewed a series of 383 consecutive stress MPI studies performed on patients undergoing workup prior to planned bariatric surgery. The study population had a mean age 42 ± 10 years, and was 83% female, with a body mass index of 49 ± 8. The majority of patients (81%) were able to exercise using either the Bruce or Modified Bruce protocol, and 67% underwent stress-only imaging. Overall SPECT MPI findings were normal in 89% and equivocal in 6% of patients. The incidence of abnormal findings on MPI was 5% (3% mild and 2% moderate-to-severe abnormalities). At 1 year, overall survival was 99.5%, with no difference between those with and without MPI abnormalities. Similarly, the incidence of post-operative cardiac events was very low (2%), and mostly due to atrial arrhythmias or borderline elevations of troponin.
In a typical pre-bariatric surgery population, the incidence of abnormal stress MPI is low. The majority of patients were able to use a stress-only strategy for assessment of perfusion. At 1 year the incidence of adverse cardiovascular outcomes is very low. Additional studies should be focused on determining whether any subgroup of such patients may benefit more from pre-operative stress testing.
肥胖症的管理采用减重手术的频率越来越高。在预期减重手术之前,通常会进行心肌灌注成像的应激测试作为检查的一部分。然而,对于这种适应症进行的应激 MPI 检查中出现临床显著异常的发生率尚未确定。
我们回顾性分析了 383 例连续进行的应激 MPI 研究,这些研究是在计划进行减重手术之前对患者进行检查的。研究人群的平均年龄为 42 ± 10 岁,83%为女性,体重指数为 49 ± 8。大多数患者(81%)能够使用 Bruce 或改良 Bruce 方案进行运动,67%进行了仅应激成像。总体 SPECT MPI 检查结果正常的患者占 89%,结果不确定的患者占 6%。MPI 检查异常的发生率为 5%(3%为轻度异常,2%为中重度异常)。在 1 年时,总体生存率为 99.5%,MPI 异常患者与无 MPI 异常患者之间无差异。同样,术后心脏事件的发生率也非常低(2%),主要是由于房性心律失常或肌钙蛋白轻度升高。
在典型的减重手术前人群中,异常应激 MPI 的发生率较低。大多数患者能够使用仅应激策略来评估灌注。在 1 年时,不良心血管结局的发生率非常低。应进一步研究确定此类患者中是否有任何亚组可能从术前应激测试中获益更多。