Office of Mine Safety and Health Research, National Institute for Occupational Safety and Health, Pittsburgh, Pennsylvania, USA.
Am J Ind Med. 2011 Oct;54(10):727-33. doi: 10.1002/ajim.20986. Epub 2011 Jul 14.
Particulate exposure from air pollution increases the risk of ischemic heart disease (IHD) mortality. Although coal miners are highly exposed to coal dust particulate, studies of IHD mortality risk among coal miners have had inconsistent results. Previous studies may have been biased by the healthy worker effect.
We examined the dose-response relationship between cumulative coal dust exposure, coal rank, and IHD mortality among a cohort of underground coal miners who participated in the National Study of Coal Workers' Pneumoconiosis.
After adjusting for age, smoking, and body mass index, risk of IHD mortality increased at higher levels of coal dust exposure. Mortality risk was also associated with coal rank region.
There was an increased risk of mortality from IHD associated with cumulative exposure to coal dust, and with coal rank. The effect of coal rank may be due differences in the composition of coal mine dust particulate. The association of risk of IHD mortality with cumulative particulate exposure is consistent with air pollution studies.
空气污染中的颗粒物暴露会增加缺血性心脏病（IHD）死亡率。虽然煤矿工人高度暴露于煤尘颗粒物，但关于煤矿工人 IHD 死亡率风险的研究结果并不一致。先前的研究可能受到健康工人效应的影响。
我们研究了参与全国煤矿工人尘肺研究的队列中累积煤尘暴露、煤阶与 IHD 死亡率之间的剂量反应关系。
在调整年龄、吸烟和体重指数后，较高水平的煤尘暴露与 IHD 死亡率增加相关。死亡率风险也与煤阶区域有关。
累积暴露于煤尘以及煤阶与 IHD 死亡率相关的死亡风险增加有关。煤阶的影响可能是由于煤矿尘粒组成的差异所致。与累积颗粒物暴露相关的 IHD 死亡率风险的关联与空气污染研究一致。
