Department of Medical Radiation Physics, Clinical Sciences, Lund, Lund University, Sweden.
J Magn Reson Imaging. 2011 Sep;34(3):511-7. doi: 10.1002/jmri.22654. Epub 2011 Jul 14.
To investigate if resting-state functional MRI (fMRI) reliably can serve as a complement to task-based fMRI for presurgical mapping of the sensorimotor cortex.
Functional data were obtained in 10 healthy volunteers using a 3 Tesla MRI system. Each subject performed five bilateral finger tapping experiments interleaved with five resting-state experiments. Following preprocessing, data from eight volunteers were further analyzed with the general linear model (finger tapping data) and independent component analysis (rest data). Test-retest reliability estimates (hit rate and false alarm rate) for resting-state fMRI activation of the sensorimotor network were compared with the reliability estimates for task-evoked activation of the sensorimotor cortex. The reliability estimates constituted a receiver operating characteristics curve from which the area under the curve (AUC) was calculated. Statistical testing was performed to compare the two groups with respect to reliability.
The AUC was generally higher for the task experiments, although median AUC was not significantly different on a group level. Also, the two groups showed comparable levels of within-group variance.
Test-retest reliability was comparable between resting-state measurements and task-based fMRI, suggesting that presurgical mapping of functional networks can be a supplement to task-based fMRI in cases where patient status excludes task-based fMRI.
研究静息态功能磁共振成像（fMRI）是否能可靠地作为任务态 fMRI 的补充，用于术前感觉运动皮层的定位。
使用 3T MRI 系统在 10 名健康志愿者中获得功能数据。每位受试者进行 5 次双侧手指敲击实验，穿插 5 次静息状态实验。在预处理后，进一步用一般线性模型（手指敲击数据）和独立成分分析（静息数据）分析了 8 名志愿者的数据。比较了静息态 fMRI 激活感觉运动网络的测试-重测可靠性估计（击中率和虚报率）与任务诱发感觉运动皮层激活的可靠性估计。可靠性估计构成了接收者操作特性曲线，从中计算出曲线下面积（AUC）。进行了统计检验，以比较两组之间的可靠性。
任务实验的 AUC 普遍较高，尽管组水平上的中位数 AUC 没有显著差异。此外，两组之间的组内方差水平相当。
静息态测量与任务态 fMRI 之间的测试-重测可靠性相当，这表明在患者状况排除任务态 fMRI 的情况下，功能网络的术前定位可以作为任务态 fMRI 的补充。
