Departament de Química Física i Inorgànica, Universitat Rovira i Virgili, Campus Sescelades, C/Marcel·lí Domingo, s/n. 43007 Tarragona, Spain.
J Am Chem Soc. 2011 Aug 31;133(34):13634-45. doi: 10.1021/ja204948k. Epub 2011 Aug 4.
A modular set of phosphite-oxazoline (P,N) ligands has been applied to the title reaction. Excellent ligands have been identified for a range of substrates, including previously challenging terminally disubstituted olefins, where we now have reached enantioselectivities of 99% for a range of substrates. The selectivity is best for minimally functionalized substrates with at least a moderate size difference between geminal groups. A DFT study has allowed identification of the preferred pathway. Computational prediction of enantioselectivities gave very good accuracy.
一套模块化的亚膦酸-噁唑啉（P，N）配体已被应用于该反应。已经为一系列底物鉴定了出色的配体，包括以前具有挑战性的末端二取代烯烃，我们现在已经为一系列底物达到了 99%的对映选择性。选择性最好的是具有最小官能团的底物，偕二甲基之间至少有适度的尺寸差异。DFT 研究允许确定首选途径。对映选择性的计算预测具有非常高的准确性。
