长期给予苯环利定后大鼠脑内[3H]-TCP结合的变化。

Alterations in rat brain [3H]-TCP binding following chronic phencyclidine administration.

作者信息

Massey B W, Wessinger W D

机构信息

Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock 72205.

出版信息

Life Sci. 1990;47(24):PL139-43. doi: 10.1016/0024-3205(90)90163-l.

DOI:10.1016/0024-3205(90)90163-l

PMID:2176262

Abstract

Rats were chronically infused with phencyclidine (PCP, 13.3 mg PCP.HCl/kg/day) or saline, s.c., for 10 days using osmotic minipumps (n = 5 for each group). Twenty-four hours after the cessation of dosing, the rats were sacrificed, and brains were removed for analysis of PCP receptor binding. Saturation studies of the binding of [3H]-TCP to brain homogenates revealed statistically significant increases in the maximum binding capacity (Bmax) and decreases in the affinity for [3H]-TCP in the PCP-treated group.

摘要

使用渗透微型泵对大鼠进行为期10天的苯环利定（PCP，13.3毫克盐酸PCP/千克/天）或生理盐水的皮下慢性输注（每组n = 5）。给药停止24小时后，处死大鼠，取出大脑用于分析PCP受体结合情况。对[3H]-TCP与脑匀浆结合的饱和研究显示，PCP处理组的最大结合容量（Bmax）有统计学意义的增加，且对[3H]-TCP的亲和力降低。