Department of Systems Biology & Bioinformatics, University of Rostock, 18051 Rostock, Germany.
Prog Biophys Mol Biol. 2011 Aug;106(2):426-34. doi: 10.1016/j.pbiomolbio.2011.06.013. Epub 2011 Jul 6.
Originally implicated in the regulation of survival, proliferation and differentiation of haematopoietic cells, the JAK-STAT pathway has also been linked to developmental processes, growth control and maintenance of homeostasis in a variety of other cells and tissues. Although it remains a complex system, its relative simplicity and the availability of molecular data makes it particularly attractive for modelling approaches. In this review, we will focus on JAK-STAT signalling in the context of cancer and present efforts to investigate signalling dynamics with the help of mathematical models. We describe the modelling workflow that realises a systems biology approach and give an example for interferon-γ signalling in pancreatic stellate cells.
最初涉及造血细胞的存活、增殖和分化的调节，JAK-STAT 途径也与各种其他细胞和组织的发育过程、生长控制和内稳态的维持有关。尽管它仍然是一个复杂的系统，但它相对简单，并且有分子数据的可用性，这使得它特别适合建模方法。在这篇综述中，我们将重点介绍癌症背景下的 JAK-STAT 信号，并展示借助数学模型研究信号动力学的努力。我们描述了实现系统生物学方法的建模工作流程，并给出了胰腺星状细胞中干扰素-γ信号的示例。
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