Biomedical Sciences Department, Dstl, Porton Down, Wiltshire, SP4 0JQ, UK.
J Virol Methods. 2011 Oct;177(1):123-7. doi: 10.1016/j.jviromet.2011.06.021. Epub 2011 Jul 5.
Understanding the ability to survive in an aerosol leads to better understanding of the hazard posed by pathogenic organisms and can inform decisions related to the control and management of disease outbreaks. This basic survival information is sometimes lacking for high priority select agents such as the filoviruses which cause severe disease with high case fatality rates and can be acquired through the aerosol route. Microthreads in the form of spiders' webs were used to capture aerosolised filoviruses, and the decay rates of Zaire ebolavirus and Marburgvirus were determined. Results were compared to data obtained using a Goldberg drum to measure survival as a dynamic aerosol. The two methods of obtaining aerostability information are compared.
了解在气溶胶中存活的能力可以更好地了解致病生物体带来的危害，并为控制和管理疾病爆发的决策提供信息。对于高优先级选择剂，如引起严重疾病且病死率高并可通过气溶胶途径获得的丝状病毒，有时会缺乏这种基本的生存信息。蜘蛛丝形式的微丝被用来捕获气溶胶化的丝状病毒，并确定了扎伊尔埃博拉病毒和马尔堡病毒的衰减率。结果与使用戈德堡滚筒测量作为动态气溶胶的存活情况获得的数据进行了比较。比较了获得气溶胶稳定性信息的两种方法。
