Pro Persona, Department of Old Age Psychiatry, Arnhem, the Netherlands.
Gen Hosp Psychiatry. 2011 Jul-Aug;33(4):412.e5-8. doi: 10.1016/j.genhosppsych.2011.04.012. Epub 2011 Jun 8.
Two elderly patients with dementia-related behavioral problems developed rash, edema, eosinophilia and systemic symptoms after administration of carbamazepine. Drug reaction with eosinophilia and systemic symptoms (DRESS) was diagnosed with some delay. The relevance and complexity of recognizing DRESS are shown. Symptoms occur 1 to 8 weeks after start of carbamazepine, progress slowly and are similar to those in infections and neoplastic disorders. DRESS is a severe and potentially fatal complication, occurring in 1 of every 1000 to 10,000 patients using antiepileptic drugs. Treatment consists of immediate withdrawal of the offending drug, while reexposure should be avoided. First-degree relatives need to be informed about being at increased risk.
两位老年痴呆症相关行为问题患者在服用卡马西平后出现皮疹、水肿、嗜酸性粒细胞增多和全身症状。药物引起的嗜酸性粒细胞增多和全身症状（DRESS）的诊断有些延迟。本文展示了识别 DRESS 的相关性和复杂性。症状在开始服用卡马西平后 1 至 8 周出现，进展缓慢，与感染和肿瘤性疾病相似。DRESS 是一种严重且潜在致命的并发症，在使用抗癫痫药物的 1000 至 10000 名患者中发生 1 例。治疗包括立即停用致病药物，同时应避免再次暴露。需要告知一级亲属存在风险增加。
