Biochemistry Department, Faculty of Pharmacy, Zagazig University, Egypt.
Brain Res Bull. 2011 Aug 10;86(1-2):22-8. doi: 10.1016/j.brainresbull.2011.07.001. Epub 2011 Jul 7.
Doxorubicin (DOX) is considered one of the most important chemotherapeutic agents that is used for the treatment of solid tumors. Its long-term use can cause neurodegenerative disorders due to its prolonged activation of microglia. The present study proved that the use of epicatechin prior to DOX treatment significantly attenuated not only the increase in TNF-α, iNOS and NF-κB expressions but also the increase in TNF-α and total nitrite levels in brain tissue when compared with rats treated with DOX-only. Thus, our study revealed that epicatechin can be used for the treatment of neuroinflammation and also for preventing the development of neurodegenerative disease during antineoplastic therapy because of its protective role in attenuation of neurotoxic pro-inflammatory mediators including TNF-α, NF-κB, and iNOS.
多柔比星（DOX）被认为是最重要的化疗药物之一，用于治疗实体瘤。其长期使用会导致神经退行性疾病，因为它会长期激活小胶质细胞。本研究证明，与单独使用 DOX 的大鼠相比，在 DOX 治疗前使用表儿茶素可显著减轻 TNF-α、iNOS 和 NF-κB 表达的增加，以及脑组织中 TNF-α 和总亚硝酸盐水平的增加。因此，我们的研究表明，表儿茶素可用于治疗神经炎症，并可预防抗肿瘤治疗期间神经退行性疾病的发生，因为它在减轻包括 TNF-α、NF-κB 和 iNOS 在内的神经毒性促炎介质方面发挥保护作用。
