Adv Carbohydr Chem Biochem. 2011;65:10-43. doi: 10.1016/B978-0-12-385520-6.00002-9.
An account is given of the life, scientific contributions, and passing of Laurance David Hall (1938-2009), including his early history and education at the University of Bristol, UK, and the synthesis and NMR spectroscopy of carbohydrates and other natural products during ∼20 years of research and teaching at the University of British Columbia in Vancouver, Canada. Lists of graduate students, post-doctoral fellows, and sabbatical visitors are provided for this period. Following a generous endowment by Dr. Herchel Smith, Professor Hall built a new Department of Medicinal Chemistry at Cambridge University, UK, and greatly expanded his researches into the technology and applications of magnetic resonance imaging (MRI) and zero quantum NMR. MRI technology was applied both to medical problems such as the characterization of cartilage degeneration in knee joints, the measurement of ventricular function, lipid localization in animal models of atherosclerosis, paramagnetic metal complexes of polysaccharides as contrast agents, and studies of many other anatomical features, but also to several aspects of materials analysis, including food analyses, process control, and the elucidation of such physical phenomena as the flow of liquids through porous media, defects in concrete, and the visualization of fungal damage to wood. Professor Hall's many publications, patents, lectures, and honors and awards are described, and also his successful effort to keep the Asilomar facility in Pacific Grove, California as the alternating venue for the annual Experimental NMR Conference. Two memorial services for Professor Hall are remembered.
本文介绍了 Laurence David Hall（1938-2009 年）的生平、科研贡献和逝世，包括他在英国布里斯托大学的早期历史和教育背景，以及在加拿大温哥华不列颠哥伦比亚大学从事约 20 年的科研和教学工作期间，对碳水化合物和其他天然产物的合成和 NMR 光谱学的研究。在此期间，列出了他的研究生、博士后研究员和休假访问学者的名单。在赫歇尔·史密斯博士的慷慨捐赠下，霍尔教授在英国剑桥大学建立了一个新的药物化学系，并极大地扩展了他在磁共振成像（MRI）和零量子 NMR 技术及其应用方面的研究。MRI 技术不仅应用于医学问题，如膝关节软骨退化的特征描述、心室功能的测量、动脉粥样硬化动物模型中的脂质定位、多糖的顺磁金属配合物作为造影剂，以及对许多其他解剖特征的研究，还应用于材料分析的几个方面，包括食品分析、过程控制，以及阐明液体通过多孔介质的流动、混凝土缺陷和真菌对木材的破坏等物理现象。本文还介绍了霍尔教授的许多出版物、专利、演讲、荣誉和奖项，以及他成功地将加利福尼亚州太平洋格罗夫的阿西洛马设施保留为年度实验 NMR 会议的交替场地。本文还回忆了两次霍尔教授的追悼会。
