增强子：从发育遗传学到常见人类疾病的遗传学。
Enhancers: from developmental genetics to the genetics of common human disease.
机构信息
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Crewe Road, Edinburgh, UK.
出版信息
Dev Cell. 2011 Jul 19;21(1):17-9. doi: 10.1016/j.devcel.2011.06.008.
PMID:21763601
Abstract
In mammals, long-range gene regulation became apparent through simple Mendelian disease genetics in human and developmental genetics in the mouse. Can the insights into gene control, provided by the study of these enhancers, help us understand the functional significance of sequence variation associated with common/complex human disease and quantitative traits?
摘要
在哺乳动物中，通过人类的简单孟德尔疾病遗传学和小鼠的发育遗传学，长程基因调控变得明显。这些增强子研究提供的关于基因控制的见解，是否有助于我们理解与常见/复杂人类疾病和数量性状相关的序列变异的功能意义？
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