Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA.
Dev Cell. 2011 Jul 19;21(1):159-71. doi: 10.1016/j.devcel.2011.06.018.
The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special "state" based on novel "stem cell genes" but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.
过去十年对果蝇干细胞和其龛位的研究提供了关键的见解。果蝇干细胞并没有处于一种特殊的“状态”，也不依赖于新颖的“干细胞基因”，而是类似于暂时停滞的组织祖细胞。此外，单个干细胞及其下游祖细胞具有高度的动态性和可替代性，并非组织的堡垒。龛位，而不是固定的细胞谱系，通过在内部保留干细胞并抑制细胞分化来确保组织的健康，但在外部则不会。我们回顾了五个最被了解的成年果蝇干细胞，并认为干细胞和龛位的基本生物学在果蝇和小鼠之间是保守的。
