果蝇干细胞生态位：十年的发现表明对干细胞调控有了统一的认识。
Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.
机构信息
Howard Hughes Medical Institute Research Laboratories, Department of Embryology, Carnegie Institution for Science, 3520 San Martin Drive, Baltimore, MD 21218, USA.
出版信息
Dev Cell. 2011 Jul 19;21(1):159-71. doi: 10.1016/j.devcel.2011.06.018.
Abstract
The past decade of research on Drosophila stem cells and niches has provided key insights. Fly stem cells do not occupy a special "state" based on novel "stem cell genes" but resemble transiently arrested tissue progenitors. Moreover, individual stem cells and downstream progenitors are highly dynamic and dispensable, not tissue bulwarks. Niches, rather than fixed cell lineages, ensure tissue health by holding stem cells and repressing cell differentiation inside, but not outside. We review the five best-understood adult Drosophila stem cells and argue that the fundamental biology of stem cells and niches is conserved between Drosophila and mice.
摘要
过去十年对果蝇干细胞和其龛位的研究提供了关键的见解。果蝇干细胞并没有处于一种特殊的“状态”，也不依赖于新颖的“干细胞基因”，而是类似于暂时停滞的组织祖细胞。此外，单个干细胞及其下游祖细胞具有高度的动态性和可替代性，并非组织的堡垒。龛位，而不是固定的细胞谱系，通过在内部保留干细胞并抑制细胞分化来确保组织的健康，但在外部则不会。我们回顾了五个最被了解的成年果蝇干细胞，并认为干细胞和龛位的基本生物学在果蝇和小鼠之间是保守的。
相似文献
1
Drosophila stem cell niches: a decade of discovery suggests a unified view of stem cell regulation.果蝇干细胞生态位：十年的发现表明对干细胞调控有了统一的认识。
Dev Cell. 2011 Jul 19;21(1):159-71. doi: 10.1016/j.devcel.2011.06.018.
2
Stem cells and the niche: a dynamic duo.干细胞与龛：一对动态组合。
Cell Stem Cell. 2010 Feb 5;6(2):103-15. doi: 10.1016/j.stem.2010.01.011.
3
Recent advances in Drosophila stem cell biology.果蝇干细胞生物学的最新进展。
Int J Dev Biol. 2009;53(8-10):1329-39. doi: 10.1387/ijdb.072431jp.
4
Insulin levels control female germline stem cell maintenance via the niche in Drosophila.胰岛素水平通过果蝇中的微环境控制雌性生殖系干细胞的维持。
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1117-21. doi: 10.1073/pnas.0809144106. Epub 2009 Jan 9.
5
Local signaling within stem cell niches: insights from Drosophila.干细胞龛内的局部信号：来自果蝇的见解。
Curr Opin Cell Biol. 2012 Apr;24(2):225-31. doi: 10.1016/j.ceb.2012.01.004. Epub 2012 Jan 30.
6
Finding a niche: studies from the Drosophila ovary.找到一个合适的位置：来自果蝇卵巢的研究。
Stem Cell Res Ther. 2011 Nov 25;2(6):45. doi: 10.1186/scrt86.
7
A transient niche regulates the specification of Drosophila intestinal stem cells.一个短暂的生态位调节果蝇肠道干细胞的特化。
Science. 2010 Jan 8;327(5962):210-3. doi: 10.1126/science.1181958.
8
An empty Drosophila stem cell niche reactivates the proliferation of ectopic cells.一个空的果蝇干细胞微环境会重新激活异位细胞的增殖。
Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4633-8. doi: 10.1073/pnas.0830856100. Epub 2003 Apr 3.
9
The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling.内胚层通过 Delta-Notch 信号指定果蝇生殖细胞的中胚层壁龛。
Development. 2011 Apr;138(7):1259-67. doi: 10.1242/dev.056994. Epub 2011 Feb 24.
10
Primer and interviews: The dynamic stem cell niche.基础与访谈：动态干细胞生态位。
Dev Dyn. 2011 Mar;240(3):737-43. doi: 10.1002/dvdy.22566. Epub 2011 Feb 14.
引用本文的文献
1
miR-932 Suppresses the Expression of Germline-Specific in Somatic Testis Hub Cells.miR-932抑制睾丸体细胞枢纽细胞中生殖系特异性基因的表达。
Dev Reprod. 2025 Jun;29(2):55-61. doi: 10.12717/DR.2025.29.2.55. Epub 2025 Jun 30.
2
Males Differentially Express Small Proteins Regulating Stem Cell Division Frequency in Response to Mating.雄性在交配时会差异表达调控干细胞分裂频率的小蛋白质。
J Dev Biol. 2025 Jun 23;13(3):21. doi: 10.3390/jdb13030021.
3
Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis.雌性生殖系特异性蛋白樱花与Otu相互作用，对生殖系干细胞的更新、分化及卵子发生至关重要。
Elife. 2025 Jul 15;13:RP103828. doi: 10.7554/eLife.103828.
4
MYCBP interacts with Sakura and Otu and is essential for germline stem cell renewal and differentiation and oogenesis.MYCBP与Sakura和Otu相互作用，对生殖系干细胞的更新、分化及卵子发生至关重要。
bioRxiv. 2025 Jul 2:2025.07.01.662550. doi: 10.1101/2025.07.01.662550.
5
Regulation of somatic stem cell and niche precursor fates and proliferation of by Wnt, JAK-STAT, Hedgehog and Hippo/Yorkie pathways during Drosophila pupal ovary development resembles the signaling framework organizing adult stem cell behavior.在果蝇蛹期卵巢发育过程中，Wnt、JAK-STAT、Hedgehog和Hippo/Yorkie信号通路对体细胞干细胞和微环境前体细胞命运及增殖的调控，类似于组织成体干细胞行为的信号框架。
bioRxiv. 2025 May 13:2025.05.08.652870. doi: 10.1101/2025.05.08.652870.
6
Tbx1 ortholog is required to establish testis stem cell niche identity in .Tbx1直系同源基因是在……中建立睾丸干细胞微环境特征所必需的。
bioRxiv. 2025 May 15:2025.05.09.653127. doi: 10.1101/2025.05.09.653127.
7
Role of Hemocytes in the Aging of Drosophila Male Germline.血细胞在果蝇雄性生殖系衰老中的作用
Cells. 2025 Feb 19;14(4):315. doi: 10.3390/cells14040315.
8
PIWI proteins and piRNAs: key regulators of stem cell biology.PIWI蛋白与piRNA：干细胞生物学的关键调控因子。
Front Cell Dev Biol. 2025 Feb 6;13:1540313. doi: 10.3389/fcell.2025.1540313. eCollection 2025.
9
Female-germline specific protein Sakura interacts with Otu and is crucial for germline stem cell renewal and differentiation and oogenesis.雌性生殖系特异性蛋白樱花与卵巢肿瘤相关去泛素化酶相互作用，对生殖系干细胞的更新、分化及卵子发生至关重要。
bioRxiv. 2025 Jun 4:2024.10.04.616675. doi: 10.1101/2024.10.04.616675.
10
An unscheduled switch to endocycles induces a reversible senescent arrest that impairs growth of the Drosophila wing disc.细胞内周期的非计划性切换会诱导可恢复的衰老停滞，从而损害果蝇翅盘的生长。
PLoS Genet. 2024 Sep 3;20(9):e1011387. doi: 10.1371/journal.pgen.1011387. eCollection 2024 Sep.
本文引用的文献
1
Long-term live imaging provides new insight into stem cell regulation and germline-soma coordination in the Drosophila ovary.长期活体成像为果蝇卵巢中干细胞调控和生殖细胞-体细胞协调提供了新的见解。
Development. 2011 Jun;138(11):2207-15. doi: 10.1242/dev.065508.
2
lines and bowl affect the specification of cyst stem cells and niche cells in the Drosophila testis.线和碗影响果蝇睾丸中的囊干细胞和壁龛细胞的规格。
Development. 2011 May;138(9):1687-96. doi: 10.1242/dev.057364.
3
Loss of lysine-specific demethylase 1 nonautonomously causes stem cell tumors in the Drosophila ovary.赖氨酸特异性去甲基化酶 1 的缺失非自主性地导致果蝇卵巢中的干细胞肿瘤。
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7064-9. doi: 10.1073/pnas.1015874108. Epub 2011 Apr 11.
4
Development of the Drosophila entero-endocrine lineage and its specification by the Notch signaling pathway.果蝇肠内分泌谱系的发育及其由 Notch 信号通路决定。
Dev Biol. 2011 May 15;353(2):161-72. doi: 10.1016/j.ydbio.2011.01.039. Epub 2011 Mar 5.
5
Distinct effects of nuclear membrane localization on gene transcription silencing in Drosophila S2 cells and germ cells.核膜定位对果蝇 S2 细胞和生殖细胞中基因转录沉默的不同影响。
J Genet Genomics. 2011 Feb;38(2):55-61. doi: 10.1016/j.jcg.2011.01.002. Epub 2011 Feb 23.
6
Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioning.果蝇精巢中的囊干细胞的不对称分裂是通过后期纺锤体重定位来保证的。
Development. 2011 Mar;138(5):831-7. doi: 10.1242/dev.057901.
7
Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling.Brat 通过控制限制 BMP 信号的双稳态开关来促进干细胞分化。
Dev Cell. 2011 Jan 18;20(1):72-83. doi: 10.1016/j.devcel.2010.11.019.
8
Dynamics between stem cells, niche, and progeny in the hair follicle.毛囊中的干细胞、龛和祖细胞之间的动力学。
Cell. 2011 Jan 7;144(1):92-105. doi: 10.1016/j.cell.2010.11.049.
9
Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection.果蝇 EGFR 信号通路在感染后协调干细胞增殖和肠道重塑。
BMC Biol. 2010 Dec 22;8:152. doi: 10.1186/1741-7007-8-152.
10
EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila.EGFR/Ras/MAPK 信号通路介导果蝇成年中肠上皮细胞的稳态和再生。
Cell Stem Cell. 2011 Jan 7;8(1):84-95. doi: 10.1016/j.stem.2010.11.026. Epub 2010 Dec 16.
Zotero 插件