Roubertie A, Masson F, de Villepin-Touzery A, Suau B, Barbanel G, Rideau A, Cambonie G
Neuropédiatrie, Département de Pédiatrie, Pôle Enfant, Hôpital Arnaud-de-Villeneuve, 371 av du Doyen G. Giraud, 34295 Montpellier cedex 5, France.
Arch Pediatr. 2011 Jul;18 Suppl 2:S56-64. doi: 10.1016/S0929-693X(11)71092-2.
For several decades, experimental studies have sought to explain the biological causes of newborn seizures and to assess the anatomical and functional consequences. Laboratory studies have shown that prolonged or repeated seizures disturb central nervous system development and may predispose to later epilepsy or cognitive deficits. Although these findings have not been clinically demonstrated in humans, several observations suggest that neonatal seizures have a deleterious effect on the immature brain and generate long-term sequelae. No therapeutic trial, however, has directly demonstrated the benefits of treatment, underlining the need for controlled studies that integrate the advances in electroencephalographic monitoring and pharmacology of anticonvulsant drugs.
几十年来，实验研究一直试图解释新生儿惊厥的生物学原因，并评估其解剖学和功能后果。实验室研究表明，长时间或反复惊厥会干扰中枢神经系统发育，并可能易患后期癫痫或认知缺陷。尽管这些发现在人类中尚未得到临床证实，但一些观察结果表明，新生儿惊厥会对未成熟大脑产生有害影响，并产生长期后遗症。然而，尚无治疗试验直接证明治疗的益处，这突出表明需要进行对照研究，整合脑电图监测和抗惊厥药物药理学方面的进展。
