Key Laboratory of Laboratory Medicine, Ministry of Education, Wenzhou Medical College, Wenzhou, Zhejiang 325035, China.
Cytokine. 2011 Nov;56(2):351-5. doi: 10.1016/j.cyto.2011.05.022. Epub 2011 Jul 18.
A large number of studies have shown that the -1082A/G polymorphism (rs1800896) in the Interleukin-10 gene (IL-10) is implicated in the susceptibility to rheumatoid arthritis (RA). However, the results are inconsistent and inconclusive. The aim of this study is to analyze the association between the -1082A/G polymorphism in the IL-10 gene and the RA risk by meta-analysis. A total of 1480 cases and 1413 controls in 10 case-control studies were included in this meta-analysis. The results indicated that the G allele carriers (GG+GA) had a 25% decreased risk of RA, when compared with the homozygote AA (odds ratio (OR)=0.75, 95% confidence interval (CI): 0.59-0.93). In the analysis in Europeans, significant decreased risks were associated with the G allele carriers (OR=0.73 and 95% CI: 0.57-0.93 for GG+GA vs. AA). The results from this meta-analysis provide evidence for the association between the IL-10 -1082A/G polymorphism and the risk of RA. To further evaluate gene×gene and gene×environment interactions between the polymorphisms in the IL-10 gene and RA risk, more studies with large groups of patients are required.
大量研究表明，白细胞介素-10 基因（IL-10）中的-1082A/G 多态性（rs1800896）与类风湿关节炎（RA）的易感性有关。然而，结果并不一致，也没有定论。本研究旨在通过荟萃分析分析 IL-10 基因中的-1082A/G 多态性与 RA 风险之间的关联。共有 10 项病例对照研究纳入了 1480 例病例和 1413 例对照。结果表明，与纯合子 AA 相比，G 等位基因携带者（GG+GA）患 RA 的风险降低了 25%（比值比（OR）=0.75，95%置信区间（CI）：0.59-0.93）。在欧洲人群的分析中，与 G 等位基因携带者（OR=0.73，95%CI：0.57-0.93，GG+GA 与 AA 相比）显著降低了 RA 的风险。本荟萃分析的结果为 IL-10-1082A/G 多态性与 RA 风险之间的关联提供了证据。为了进一步评估 IL-10 基因中的多态性与 RA 风险之间的基因×基因和基因×环境相互作用，需要更多的大样本患者研究。
