Zhao Xiao-lin, Yan Jian-qun, Chen Ke, Yang Xue-juan, Li Jin-rong, Zhang Yuan
Department of Physiology and Pathophysiology, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun;31(7):1138-41.
To examine the role of glutaminergic neurons in the transmission and integration of the sweat taste information in the brain stem and the amygdala.
Conscious Sprague-Dawley rats were subjected to oral sweet taste or water (control) stimulations. The activated neurons were identified by detecting c-Fos expression in taste-related brain areas, and the glutaminergic neurons by detecting vesicular glutamate transpoter-3 (VGLUT3).
Compared with control group, the rats with oral sucrose solution stimulation exhibited significantly increased c-Fos-expressing and double-labeled neurons in the nucleus of the solitary tract (NST), the parabrachial nucleus (PBN) and the amygdala.
Neurons in the NST, PBN and amygdala are activated after oral sweet taste stimulation. The sweet taste perception at different levels in the CNS is partly mediated by glutamate.
研究谷氨酰胺能神经元在脑干和杏仁核中汗液味觉信息传递与整合中的作用。
对清醒的斯普拉格-道利大鼠进行口服甜味或水（对照）刺激。通过检测味觉相关脑区中c-Fos的表达来鉴定激活的神经元，通过检测囊泡谷氨酸转运体-3（VGLUT3）来鉴定谷氨酰胺能神经元。
与对照组相比，口服蔗糖溶液刺激的大鼠在孤束核（NST）、臂旁核（PBN）和杏仁核中，c-Fos表达神经元和双标神经元显著增加。
口服甜味刺激后，NST、PBN和杏仁核中的神经元被激活。中枢神经系统不同水平的甜味感知部分由谷氨酸介导。
