Qin Yan-ru, Tang Hong, Qiao Jun-jing, Li Fang-fang, Ai Jiao-yu
Department of Clinical Oncology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun;31(7):1216-9.
To investigate the role of fascin, an actin bundling protein, in the development and progression of human esophageal squamous cell carcinoma (ESCC), and explore its association with the clinicopathologic characteristics and 5-year survival of the patients.
Using tissue array and immunohistochemistry, the expression of fascin was determined in 241 ESCC tissues and the corresponding normal esophageal mucosal tissues.
ESCC tissues showed a significantly higher overexpression rate of fascin than the corresponding normal esophageal mucosal tissues (68.9% vs 15.5%, P<0.05). The overexpression of fascin was correlated to lymph node metastasis and TMN stage, but not to the patients' age, gender, tumor differentiation and general classification. Survival analysis showed that abnormal expression of fascin was associated with the 5-year survival rate of patients with ESCC.
The abnormal expression of fascin may play an important role in the progression of ESCC, and detection of fascin expression may have important prognostic values.
研究肌动蛋白成束蛋白fascin在人食管鳞状细胞癌（ESCC）发生发展中的作用，并探讨其与患者临床病理特征及5年生存率的关系。
采用组织芯片和免疫组织化学方法，检测241例ESCC组织及相应正常食管黏膜组织中fascin的表达。
ESCC组织中fascin的过表达率显著高于相应正常食管黏膜组织（68.9%对15.5%，P<0.05）。fascin的过表达与淋巴结转移及TMN分期相关，但与患者年龄、性别、肿瘤分化程度及大体分型无关。生存分析显示，fascin的异常表达与ESCC患者的5年生存率相关。
fascin的异常表达可能在ESCC进展中起重要作用，检测fascin表达可能具有重要的预后价值。
