University of Duisburg-Essen, Germany.
Cephalalgia. 2011 Aug;31(11):1181-8. doi: 10.1177/0333102411412629. Epub 2011 Jul 15.
Central facilitation of trigeminal pain processing and deficient habituation was observed in different headache and facial pain disorders. This overactivation seems to be primarily associated with chronic pain states.
To investigate the function of the trigeminal nociceptive system in patients with hypnic headache (HH).
Fifteen HH patients according International Classification of Headache Disorders II criteria and 15 age- and gender-matched healthy controls were investigated using the nociceptive blink reflex (nBR) and trigeminal pain-related evoked potentials (PREP).
nBR and PREP responses showed no significant differences comparing HH patients and healthy controls. Moreover, no habituation deficit was detected in HH patients.
Central facilitation and change in habituation do not seem to be a crucial part in the pathophysiology of HH despite the chronic nature of this disease. Facilitation or habituation deficit does not seem to be exclusively related to chronic pain disorders in general. Further research is needed to illuminate the pathophysiology of HH.
在不同的头痛和面部疼痛障碍中，观察到三叉神经疼痛处理的中枢易化和习惯缺失。这种过度激活似乎主要与慢性疼痛状态有关。
研究睡眠性头痛（HH）患者三叉神经伤害感受系统的功能。
根据国际头痛疾病分类第二版标准，对 15 名 HH 患者和 15 名年龄和性别匹配的健康对照者进行了伤害性眨眼反射（nBR）和三叉神经痛相关诱发电位（PREP）的研究。
HH 患者与健康对照组相比，nBR 和 PREP 反应无显著差异。此外，HH 患者未发现习惯缺失。
尽管 HH 是一种慢性疾病，但中枢易化和习惯缺失的改变似乎不是 HH 病理生理学的关键部分。易化或习惯缺失缺陷似乎与一般的慢性疼痛障碍并非完全相关。需要进一步研究阐明 HH 的病理生理学。
