甲状腺功能减退和亢进对[3H]-尼群地平与心肌及脑膜结合的影响。
Effect of hypo- and hyperthyroidism on binding of [3H]-nitrendipine to myocardial and brain membranes.
作者信息
Kosinski C, Gross G, Hanft G
机构信息
Department of Pharmacology, University of Essen, Federal Republic of Germany.
出版信息
Br J Clin Pharmacol. 1990;30 Suppl 1(Suppl 1):128S-130S. doi: 10.1111/j.1365-2125.1990.tb05483.x.
Abstract
The density of calcium channel binding sites as determined by [3H]-nitrendipine binding was found to be decreased in hearts of hyperthyroid rats but hardly altered by hypothyroidism. In contrast, dihydropyridine binding sites in the cerebral cortex were unaffected by dysthyroid states. Myocardial [3H]-nitrendipine binding sites were also decreased after treatment of the animals with isoprenaline but not in spontaneously hypertensive rats. These findings suggest that myocardial hypertrophy is not necessarily accompanied by a loss of calcium channels and that thyroid hormone regulates the density of [3H]-nitrendipine binding sites in a tissue-specific manner.
摘要
通过[3H]-尼群地平结合测定发现，甲状腺功能亢进大鼠心脏中钙通道结合位点的密度降低，但甲状腺功能减退几乎未使其改变。相比之下，甲状腺功能紊乱状态对大脑皮质中二氢吡啶结合位点没有影响。用异丙肾上腺素处理动物后，心肌[3H]-尼群地平结合位点也减少，但自发性高血压大鼠未出现这种情况。这些发现表明，心肌肥大不一定伴随着钙通道的丧失，并且甲状腺激素以组织特异性方式调节[3H]-尼群地平结合位点的密度。
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本文引用的文献
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Binding of [3H]nitrendipine to heart and brain membranes from normotensive and spontaneously hypertensive rats.[3H]尼群地平与正常血压及自发性高血压大鼠心脏和脑膜的结合。
Eur J Pharmacol. 1983 Mar 25;88(2-3):277-8. doi: 10.1016/0014-2999(83)90020-1.
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Comparison of [3H]nitrendipine binding to heart membranes of normotensive and spontaneously hypertensive rats.[3H]尼群地平与正常血压大鼠和自发性高血压大鼠心脏膜结合的比较。
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Thyroid-dependent alterations of myocardial adrenoceptors and adrenoceptor-mediated responses in the rat.大鼠心肌肾上腺素能受体的甲状腺依赖性改变及肾上腺素能受体介导的反应
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