胰岛素对人β-肾上腺素能受体的作用。
Effects of insulin on human beta-adrenoceptors.
作者信息
Sager G
机构信息
Department of Pharmacology, University of Tromsø, Norway.
出版信息
Br J Clin Pharmacol. 1990;30 Suppl 1(Suppl 1):139S-141S. doi: 10.1111/j.1365-2125.1990.tb05486.x.
Abstract
The effect of insulin on beta-adrenoceptor stimulation and binding in mononuclear leucocytes from healthy subjects was studied. After 1 min exposure to insulin, the sensitivity and maximum response to (-)-isoprenaline and the number of beta-adrenoceptors increased. After 35 min exposure to insulin, the sensitivity and maximal response to (-)-isoprenaline stimulation were lower than the pretreatment values. The beta-adrenoceptor density was similar to the control value after 35 min exposure to insulin. The present observations may account for some of the cardiovascular effects of insulin.
摘要
研究了胰岛素对健康受试者单核白细胞中β-肾上腺素能受体刺激和结合的影响。暴露于胰岛素1分钟后，对（-）-异丙肾上腺素的敏感性和最大反应以及β-肾上腺素能受体的数量增加。暴露于胰岛素35分钟后，对（-）-异丙肾上腺素刺激的敏感性和最大反应低于预处理值。暴露于胰岛素35分钟后，β-肾上腺素能受体密度与对照值相似。本观察结果可能解释了胰岛素的一些心血管效应。
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