一种通过使用“可挥发”载体合成3,4-二取代-2-氨基噻唑鎓衍生物的简便方法。
A Facile Approach to the Synthesis of 3,4-Disubstituted-2-Aminothiazolium Derivatives through the Use of A "Volatilizable" Support.
作者信息
Li Yangmei, Giulianotti Marc, Houghten Richard A
机构信息
Torrey Pines Institute for Molecular Studies, 11350 Village Parkway, Port St. Lucie, FL 34987.
出版信息
Tetrahedron Lett. 2010 Oct 27;51(43):5637-5639. doi: 10.1016/j.tetlet.2010.08.026.
Abstract
A facile solid-phase synthetic approach to the synthesis of 3,4-disubstituted-2-aminothiazolium derivatives was reported. Functionalized aminomethylphenyl silica gel was used as a "volatilizable" support. The products were cleaved with 10% HF and were obtained in high yields and purities.
摘要
报道了一种简便的固相合成方法用于合成3,4-二取代-2-氨基噻唑鎓衍生物。功能化的氨甲基苯基硅胶被用作“可挥发”载体。产物用10%的氢氟酸裂解，以高收率和高纯度得到。
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