Meyer Björn, Johnson Sheri L, Winters Ray
University of Miami, Department of Psychology.
J Psychopathol Behav Assess. 2001 Sep 1;23(3):133-143. doi: 10.1023/A:1010929402770.
Over the past 10 years, theorists have suggested that bipolar disorder symptoms result from increases and decreases in the activity of the Behavioral Activation or Facilitation System (BAS or BFS) and the Behavioral Inhibition System (BIS). These neurobehavioral systems are thought to determine the intensity of affective and behavioral responses to incentives and threats. This study examined cross-sectional and prospective associations of self-reported BIS and BAS with mania and depression in a sample of 59 individuals diagnosed with Bipolar I disorder. Depression was tied to BIS, pointing to the importance of sensitivity to threats in depression. However, links between BIS and depression appeared state-dependent. BAS subscales did not correlate with manic symptoms in a state-dependent manner; however, BAS (total scale and reward responsiveness subscale) predicted relative intensification of manic symptoms over time. Thus, evidence suggests that BAS sensitivity may constitute a vulnerability to mania among persons diagnosed with bipolar disorder. Discussion focuses on the integrative potential of the BIS/BAS constructs for linking psychosocial and biological research on bipolar disorder.
在过去十年中，理论家们提出双相情感障碍症状源于行为激活或促进系统（BAS或BFS）以及行为抑制系统（BIS）活动的增加和减少。这些神经行为系统被认为决定了对激励和威胁的情感及行为反应强度。本研究在59名被诊断为双相I型障碍的个体样本中，考察了自我报告的BIS和BAS与躁狂和抑郁的横断面及前瞻性关联。抑郁与BIS相关，这表明对威胁的敏感性在抑郁中很重要。然而，BIS与抑郁之间的联系似乎依赖于状态。BAS分量表与躁狂症状不存在依赖于状态的相关性；然而，BAS（总量表和奖励反应性分量表）预测了躁狂症状随时间的相对加重。因此，有证据表明BAS敏感性可能是被诊断为双相情感障碍的人患躁狂症的一个易感性因素。讨论集中在BIS/BAS结构在整合双相情感障碍的社会心理和生物学研究方面的潜力。
