Zhu Wenwei, Chen Xiongying, Wu Jie, Li Zixi, Im Hohjin, Chen Shuning, Deng Kun, Zhang Bin, Wei Chuqiao, Feng Junjiao, Zhang Manman, Yang Shaofeng, Wang He, Wang Qiang
Faculty of Psychology, Tianjin Normal University, Tianjin 300387, China.
The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China.
Int J Clin Health Psychol. 2023 Oct-Dec;23(4):100397. doi: 10.1016/j.ijchp.2023.100397. Epub 2023 Jul 28.
Hypomanic personality manifests a close link with several psychiatric disorders and its abnormality is a risk indicator for developing bipolar disorders. We systematically investigated the potential neuroanatomical and functional substrates underlying hypomanic personality trait (HPT) and its sub-dimensions (i.e., Social Vitality, Mood Volatility, and Excitement) combined with structural and functional imaging data as well as their corresponding brain networks in a large non-clinical sample across two studies (n = 464). Behaviorally, HPT, specifically Mood Volatility and Excitement, was positively associated with aggressive behaviors in both studies. Structurally, sex-specific morphological characteristics were further observed in the motor and top-down control networks especially for Mood Volatility, although HPT was generally positively associated with grey matter volumes (GMVs) in the prefrontal, temporal, visual, and limbic systems. Functionally, brain activations related to immediate or delayed losses were found to predict individual variability in HPT, specifically Social Vitality and Excitement, on the motor and prefrontal-parietal cortices. Topologically, connectome-based prediction model analysis further revealed the predictive role of individual-level morphological and resting-state functional connectivity on HPT and its sub-dimensions, although it did not reveal any links with general brain topological properties. GMVs in the temporal, limbic (e.g., amygdala), and visual cortices mediated the effects of HPT on behavioral aggression. These findings suggest that the imbalance between motor and control circuits may be critical for HPT and provide novel insights into the neuroanatomical, functional, and topological mechanisms underlying the specific temperament and its impacts on aggression.
轻躁狂人格与多种精神疾病密切相关，其异常是双相情感障碍发病的风险指标。我们结合结构和功能成像数据及其相应的脑网络，在两项研究的大型非临床样本（n = 464）中，系统地研究了轻躁狂人格特质（HPT）及其子维度（即社交活力、情绪波动和兴奋）潜在的神经解剖学和功能基础。在行为方面，两项研究中HPT，特别是情绪波动和兴奋，均与攻击行为呈正相关。在结构上，尽管HPT通常与前额叶、颞叶、视觉和边缘系统的灰质体积（GMV）呈正相关，但在运动和自上而下控制网络中进一步观察到了性别特异性形态特征，尤其是情绪波动方面。在功能上，发现与即时或延迟损失相关的大脑激活可预测运动和前额叶 - 顶叶皮质上HPT（特别是社交活力和兴奋）的个体差异。在拓扑学上，基于连接组的预测模型分析进一步揭示了个体水平形态和静息态功能连接对HPT及其子维度的预测作用，尽管未发现与一般脑拓扑属性的任何联系。颞叶、边缘系统（如杏仁核）和视觉皮质的GMV介导了HPT对行为攻击的影响。这些发现表明，运动和控制回路之间的失衡可能对HPT至关重要，并为特定气质及其对攻击行为影响的神经解剖学、功能和拓扑机制提供了新的见解。
