Fuhrman G M, Burch E G, Farr G H, King T A, Farkas E, Bolton J S
Department of Surgery, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, LA.
Ochsner J. 2000 Jan;2(1):19-23.
The initial reports of sentinel lymph node mapping for breast cancer currently appearing in the surgical literature are demonstrating the practicality and accuracy of the technique to evaluate patients for axillary nodal disease. We reviewed our initial 100 patient experience with sentinel node mapping to evaluate our ability to employ this technique in breast cancer patients. We combined a peritumoral injection of a radioactive substance and blue dye. Each sentinel node was evaluated with frozen section analysis, hematoxylin and eosin staining, and, if still negative, five re-cuts were taken from deeper levels of the node and evaluated for immunohistochemical evidence of cytokeratin staining. Sentinel node(s) were identified in all but two patients with 51% demonstrating metastasis. We have demonstrated the ability to accurately perform sentinel node mapping in the evaluation of our breast cancer patients. This exciting advance should become a standard part of breast cancer surgery.
目前发表在外科文献中的关于乳腺癌前哨淋巴结定位的初步报告，正展示出该技术在评估患者腋窝淋巴结疾病方面的实用性和准确性。我们回顾了最初100例患者的前哨淋巴结定位经验，以评估我们在乳腺癌患者中应用该技术的能力。我们将肿瘤周围注射放射性物质与蓝色染料相结合。对每个前哨淋巴结进行冰冻切片分析、苏木精和伊红染色，如果结果仍为阴性，则从淋巴结更深层次切取五片重新切片，评估细胞角蛋白染色的免疫组化证据。除两名患者外，其余所有患者均识别出前哨淋巴结，其中51%显示有转移。我们已经证明在评估乳腺癌患者时能够准确地进行前哨淋巴结定位。这一令人兴奋的进展应成为乳腺癌手术的标准组成部分。
