有毒化学物质和药物的自由基阴离子代谢产物的氧化还原循环与马库斯电子转移理论。
Redox cycling of radical anion metabolites of toxic chemicals and drugs and the Marcus theory of electron transfer.
作者信息
Mason R P
机构信息
Laboratory of Molecular Biophysics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
出版信息
Environ Health Perspect. 1990 Jul;87:237-43. doi: 10.1289/ehp.9087237.
Abstract
A wide variety of aromatic compounds are enzymatically reduced to form anion free radicals that generally contain one more electron than their parent compounds. In general, the electron donor is any of a wide variety of flavoenzymes. Once formed, these anion free radicals reduce molecular oxygen to superoxide and regenerate the parent compound unchanged. The net reaction is the oxidation of the flavoenzyme's coenzymes and the reduction of molecular oxygen. This catalytic behavior has been described as futile metabolism or redox cycling. Electron transfer theory is being applied to these reactions and, in some cases, has successfully correlated Vmax and Km with the reduction potentials of the aromatic compounds.
摘要
各种各样的芳香族化合物通过酶促还原形成阴离子自由基，这些阴离子自由基通常比其母体化合物多一个电子。一般来说，电子供体是多种黄素酶中的任何一种。一旦形成，这些阴离子自由基将分子氧还原为超氧阴离子，并使母体化合物不变地再生。净反应是黄素酶辅酶的氧化和分子氧的还原。这种催化行为被描述为无效代谢或氧化还原循环。电子转移理论正在应用于这些反应，并且在某些情况下，已经成功地将Vmax和Km与芳香族化合物的还原电位相关联。
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