甲状腺激素在小脑和大脑皮质发育中的作用。
Thyroid hormone action in cerebellum and cerebral cortex development.
作者信息
Chatonnet Fabrice, Picou Frédéric, Fauquier Teddy, Flamant Frédéric
机构信息
Institut de Génomique Fonctionnelle de Lyon, Ecole Normale Supérieure de Lyon, Université de Lyon, UMR CNRS 5242, 46 allée d'Italie, 69364 Lyon Cedex 07, France.
出版信息
J Thyroid Res. 2011;2011:145762. doi: 10.4061/2011/145762. Epub 2011 Jun 16.
Abstract
Thyroid hormones (TH, including the prohormone thyroxine (T4) and its active deiodinated derivative 3,3',5-triiodo-L-thyronine (T3)) are important regulators of vertebrates neurodevelopment. Specific transporters and deiodinases are required to ensure T3 access to the developing brain. T3 activates a number of differentiation processes in neuronal and glial cell types by binding to nuclear receptors, acting directly on transcription. Only few T3 target genes are currently known. Deeper investigations are urgently needed, considering that some chemicals present in food are believed to interfere with T3 signaling with putative neurotoxic consequences.
摘要
甲状腺激素（TH，包括前体激素甲状腺素（T4）及其活性脱碘衍生物3,3',5-三碘-L-甲状腺原氨酸（T3））是脊椎动物神经发育的重要调节因子。需要特定的转运蛋白和脱碘酶来确保T3进入发育中的大脑。T3通过与核受体结合，直接作用于转录，激活神经元和神经胶质细胞类型中的一些分化过程。目前已知的T3靶基因很少。鉴于食物中存在的一些化学物质被认为会干扰T3信号传导，并可能产生神经毒性后果，迫切需要进行更深入的研究。
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