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Pediatr Crit Care Med. 2011 Nov;12(6):e369-75. doi: 10.1097/PCC.0b013e3181fe40a7.
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Targeting antioxidant and antithrombotic biotherapeutics to endothelium.针对血管内皮的抗氧化和抗血栓生物治疗。
Semin Thromb Hemost. 2010 Apr;36(3):332-42. doi: 10.1055/s-0030-1253455. Epub 2010 May 20.
3
Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation.在血栓形成部位激活的红细胞靶向促尿激酶原酶促物介导的持续抗栓治疗。
Blood. 2010 Jun 24;115(25):5241-8. doi: 10.1182/blood-2010-01-261610. Epub 2010 Apr 21.
4
Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis.靶向循环红细胞的突变型纤溶酶原激活剂用于预防性纤溶。
J Pharmacol Exp Ther. 2010 Mar;332(3):1022-31. doi: 10.1124/jpet.109.159194. Epub 2009 Dec 1.
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The use of PEGylated liposomes to prolong circulation lifetimes of tissue plasminogen activator.聚乙二醇化脂质体用于延长组织型纤溶酶原激活剂的循环寿命。
Biomaterials. 2009 Oct;30(29):5751-6. doi: 10.1016/j.biomaterials.2009.07.021. Epub 2009 Aug 4.
6
Soluble urokinase receptor conjugated to carrier red blood cells binds latent pro-urokinase and alters its functional profile.与载体红细胞结合的可溶性尿激酶受体可结合潜在的纤溶酶原激活剂原，并改变其功能特性。
J Control Release. 2009 Nov 3;139(3):190-6. doi: 10.1016/j.jconrel.2009.07.003. Epub 2009 Jul 16.
7
Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation.红细胞偶联组织型纤溶酶原激活剂通过抑制细胞外信号调节激酶丝裂原活化蛋白激酶（ERK MAPK）的激活，预防小儿脑缺氧/缺血时脑血管舒张反应受损和组织损伤。
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Targeted delivery of thrombolytic agents: role of integrin receptors.溶栓剂的靶向递送：整合素受体的作用
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9
Erythrocyte-bound tissue plasminogen activator is neuroprotective in experimental traumatic brain injury.红细胞结合型组织纤溶酶原激活剂在实验性创伤性脑损伤中具有神经保护作用。
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Cerebrovascular thromboprophylaxis in mice by erythrocyte-coupled tissue-type plasminogen activator.通过红细胞偶联组织型纤溶酶原激活剂对小鼠进行脑血管血栓预防。
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抗血栓药物的血管靶向作用。

Vascular targeting of antithrombotic agents.

机构信息

Department of Pharmacology, University of Pennsylvania, Philadelphia, USA.

出版信息

IUBMB Life. 2011 Aug;63(8):632-9. doi: 10.1002/iub.474. Epub 2011 Jul 15.

DOI:10.1002/iub.474
PMID:21766410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3298751/
Abstract

In this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of anti-thrombotic agents to fibrin, platelets, red blood cells and endothelium.

摘要

在这篇综述中，我们讨论了当前用于预防和治疗血栓形成的药理学药物的疗效有限，并强调了将抗血栓形成药物靶向递送至纤维蛋白、血小板、红细胞和内皮细胞。