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[一例由肺癌相关低钠血症引起的味觉异常(甜味觉)病例]

[A case of sweet taste perception caused by lung cancer-related hyponatraemia].

作者信息

Eshuis Marga, Verschoor A J Arjan, Koster Ted

机构信息

Groene Hart Ziekenhuis, locatie Bleuland, afd. Interne Geneeskunde, Gouda, the Netherlands.

出版信息

Ned Tijdschr Geneeskd. 2011;155(26):A3150.

Abstract

BACKGROUND

Ageusia is known to occur in patients with lung cancer. The type of dysgeusia resulting in all food tasting sweet is, however, rare.

CASE REPORT

We describe the case of a 70-year-old woman presenting with an unpleasant sweet taste perception as the initial and only symptom of hyponatraemia. It was caused by the syndrome of inappropriate antidiuretic hormone (SIADH) secretion secondary to a small cell carcinoma of the lung. Treated by fluid restriction alone, the plasma sodium concentration increased and the sweet taste perception resolved. The exact pathophysiologic mechanism resulting in this type of dysgeusia is unclear to date.

CONCLUSION

It is important to be alert when the medical history reveals a relatively rare dysgeusia or ageusia; this could indicate a potentially serious underlying condition, including hyponatraemia caused by SIADH associated with a pulmonary malignancy.

摘要

背景

已知肺癌患者会出现味觉丧失。然而,导致所有食物尝起来都是甜味的味觉障碍类型较为罕见。

病例报告

我们描述了一名70岁女性的病例,她最初出现味觉异常,感觉所有食物都是甜味,这是低钠血症的唯一症状。其病因是肺癌小细胞癌继发抗利尿激素分泌异常综合征(SIADH)。仅通过限液治疗,血浆钠浓度升高,甜味味觉消失。导致这种味觉障碍的确切病理生理机制目前尚不清楚。

结论

当病史显示存在相对罕见的味觉障碍或味觉丧失时,保持警惕很重要;这可能表明存在潜在的严重基础疾病,包括与肺部恶性肿瘤相关的SIADH导致的低钠血症。

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