Griva M, Kubánek J
Interní oddelení, Nemocnice Kromeríz, prednosta prim. MUDr. P. Trestík.
Vnitr Lek. 2002 Oct;48(10):993-5.
Hyponatraemia is one of the most frequent disorders of the electrolyte metabolism. One of the causes may be also the syndrome of inadequate antidiuretic hormone secretion. The cause of increased production of antidiuretic hormone can be not only a pathological condition affecting the hypothalamo-pituitary system but also ectopic production of antidiuretic hormone or peptide with the same effect on the distal portion of the nephron. A classical type of malignant tumour where the syndrome of inadequate antidiuretic hormone secretion develops is small cell lung cancer. It is also known that some pharmaceutical preparations stimulate the output of antidiuretic hormone or potentiate its effect.
低钠血症是最常见的电解质代谢紊乱之一。其病因之一可能是抗利尿激素分泌不足综合征。抗利尿激素分泌增加的原因不仅可能是影响下丘脑 - 垂体系统的病理状况，还可能是抗利尿激素的异位分泌或对肾单位远端具有相同作用的肽的分泌。抗利尿激素分泌不足综合征发生的典型恶性肿瘤类型是小细胞肺癌。还已知一些药物制剂会刺激抗利尿激素的分泌或增强其作用。
