美国 300 型耐甲氧西林金黄色葡萄球菌（USA300MRSA）定植与长期护理机构居民中耐甲氧西林金黄色葡萄球菌感染的风险。

USA300 methicillin-resistant S. aureus (USA300 MRSA) colonization and the risk of MRSA infection in residents of extended-care facilities.

机构信息

Departments of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.

出版信息

Epidemiol Infect. 2012 Mar;140(3):390-9. doi: 10.1017/S0950268811001324. Epub 2011 Jul 18.

Abstract

To examine the pathogenesis of USA300 MRSA infection in long-term care residents, we performed a retrospective cohort study of 1691 adult residents of two extended-care facilities from 2003 to 2007 to assess whether the risk of subsequent MRSA infection is higher in USA300 MRSA-colonized residents compared to non-colonized residents or non-USA300 MRSA colonized residents. Six per cent of residents were colonized with USA300 MRSA; 12% of residents were colonized with non-USA300 MRSA; and 101 residents developed MRSA infection. The risk of infection was twofold higher in residents colonized with USA300 MRSA compared to residents not colonized with MRSA [adjusted hazard ratio 2·3, 95% confidence interval (CI) 1·1-4·5]. The risk of infection in USA300 MRSA-colonized residents was similar to USA300 MRSA non-colonized residents (relative risk 1·1, 95% CI 0·5-2·3). Our findings show that colonization with USA300 MRSA increases the risk of MRSA infection suggesting a similar pathogenesis.

摘要

为了研究 USA300 型耐甲氧西林金黄色葡萄球菌（MRSA）感染在长期护理居民中的发病机制，我们对 2003 年至 2007 年期间来自两家长期护理机构的 1691 名成年居民进行了回顾性队列研究，以评估与非定植居民或非 USA300 型 MRSA 定植居民相比，USA300 型 MRSA 定植居民随后发生 MRSA 感染的风险是否更高。6%的居民定植了 USA300 型 MRSA；12%的居民定植了非 USA300 型 MRSA；101 名居民发生了 MRSA 感染。与未定植 MRSA 的居民相比，定植了 USA300 型 MRSA 的居民感染的风险高两倍[校正风险比 2.3，95%置信区间（CI）1.1-4.5]。与 USA300 型 MRSA 非定植居民相比，定植了 USA300 型 MRSA 的居民感染的风险相似（相对风险 1.1，95%CI 0.5-2.3）。我们的研究结果表明，USA300 型 MRSA 定植会增加 MRSA 感染的风险，提示发病机制相似。