Zold Camila L, Kasanetz Fernando, Pomata Pablo E, Belluscio Mariano A, Escande Mariela V, Galinanes Gregorio L, Riquelme Luis A, Murer Mario Gustavo
Neural Circuit Physiology Lab., Systems Neuroscience Group, Department of Physiology and Biophysics, University of Buenos Aires School of Medicine, 2155 Paraguay St., Buenos Aires 1121, Argentina.
J Physiol Paris. 2012 Jan;106(1-2):40-6. doi: 10.1016/j.jphysparis.2011.06.002. Epub 2011 Jul 13.
Up states are a hallmark of striatal physiology. Spontaneous activity in the thalamo-cortical network drives robust plateau depolarizations in the medium spiny projection neurons of the striatum. Medium spiny neuron firing is only possible during up states and is very tightly regulated by dopamine and NMDA receptors. In a rat model of Parkinson's disease the medium spiny neurons projecting to the globus pallidus (indirect pathway) show more depolarized up states and increased firing. This is translated into abnormal patterns of synchronization between the globus pallidus and frontal cortex, which are believed to underlie the symptoms of Parkinson's disease. Here we review our work in the field and propose a mechanism through which the lack of D2 receptor stimulation in the striatum allows the establishment of fixed routes of information flow in the cortico-striato-pallidal network.
上行状态是纹状体生理学的一个标志。丘脑 - 皮质网络中的自发活动驱动纹状体中等棘状投射神经元产生强烈的平台去极化。中等棘状神经元只有在上行状态期间才可能放电，并且受到多巴胺和NMDA受体的严格调控。在帕金森病大鼠模型中，投射到苍白球的中等棘状神经元（间接通路）表现出更多的去极化上行状态和放电增加。这转化为苍白球和额叶皮质之间异常的同步模式，据信这是帕金森病症状的基础。在这里，我们回顾了我们在该领域的工作，并提出了一种机制，通过该机制纹状体中D2受体刺激的缺乏允许在皮质 - 纹状体 - 苍白球网络中建立固定的信息流途径。
