Learning Disability Psychology Service, Lynebank Hospital Halbeath Road, Dunfermline KY11 4UW, United Kingdom.
Res Dev Disabil. 2011 Nov-Dec;32(6):2183-92. doi: 10.1016/j.ridd.2011.06.018. Epub 2011 Jul 21.
Research continues to try and pinpoint the etiological role of particular genes and brain structure in autistic spectrum disorder (ASD), but despite a host of biological, genetic and neuropsychological research, the symptom profile of pervasive developmental disorders (PDDs) are not yet linked to etiological theory. Debate continues around whether or not there is one single dimension that incorporates the three criteria domains of social difficulties, communication deficits and repetitive or restrictive interests and behaviours as a unitary 'ASD' concept, or whether PDD as they are currently described represent the co-occurrence of separate sub-domains of developmental difficulties. Although the three criteria need to be met for a diagnosis of PDD to be made, the association between them remains unclear. This review highlights that the majority of the literature that looks at the triad of impairments suggests the symptom structure does not match that proposed by diagnostic manuals, and that the triad may no longer fit as the best way to conceptualize ASD.
研究继续试图确定特定基因和大脑结构在自闭症谱系障碍(ASD)中的病因作用,但尽管有大量的生物学、遗传学和神经心理学研究,广泛性发育障碍(PDD)的症状特征仍未与病因理论联系起来。关于是否存在一个单一的维度,将社交困难、沟通障碍和重复或限制性行为和兴趣这三个标准领域作为一个统一的“ASD”概念,或者目前所描述的 PDD 是否代表了不同发育困难亚领域的共同发生,仍存在争议。虽然需要满足三个标准才能做出 PDD 的诊断,但它们之间的关联仍不清楚。这篇综述强调,大多数研究这三个障碍的文献表明,症状结构与诊断手册提出的不一致,并且三联征可能不再是概念化 ASD 的最佳方式。