Departments of 1Internal Medicine and 2Cardiovascular Disease, University of Oklahoma Health Science Center, Oklahoma City, OK.
Am J Ther. 2013 Nov-Dec;20(6):e720-2. doi: 10.1097/MJT.0b013e3182192d6e.
Sertraline is a selective serotonin reuptake inhibitor, which is a commonly used drug for major depressive disorder. Most frequently reported adverse effects of sertraline in patients receiving 50-150 mg/d are dry mouth, headache, diarrhea, nausea, vomiting, sweating, and dizziness. We hereby report one of the few cases of sertraline-induced ventricular tachycardia, which has been for the first time objectively assessed by the Naranjo scale. We therefore urge the primary care physicians and the cardiologists to keep sertraline as a possible precipitating factor for evaluation of ventricular tachycardia.
舍曲林是一种选择性 5-羟色胺再摄取抑制剂,是一种常用于治疗重度抑郁症的药物。在接受 50-150mg/d 舍曲林治疗的患者中,最常报告的不良反应为口干、头痛、腹泻、恶心、呕吐、出汗和头晕。我们在此报告一例舍曲林引起的室性心动过速,这是首次通过 Naranjo 量表进行客观评估。因此,我们敦促初级保健医生和心脏病专家将舍曲林作为评估室性心动过速的可能诱发因素。