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创伤患者发生尿路感染与死亡率增加有关。

The development of a urinary tract infection is associated with increased mortality in trauma patients.

作者信息

Monaghan Sean F, Heffernan Daithi S, Thakkar Rajan K, Reinert Steven E, Machan Jason T, Connolly Michael D, Gregg Shea C, Kozloff Matthew S, Adams Charles A, Cioffi William G

机构信息

Division of Trauma and Surgical Critical Care, Department of Surgery, Warren Alpert School of Medicine, Rhode Island Hospital, Providence, Rhode Island 02903, USA.

出版信息

J Trauma. 2011 Dec;71(6):1569-74. doi: 10.1097/TA.0b013e31821e2b8f.

Abstract

BACKGROUND

In October 2008, Medicare and Medicaid stopped paying for care associated with catheter-related urinary tract infections (UTIs). Although most clinicians agree UTIs are detrimental, there are little data to support this belief.

METHODS

This is a retrospective review of trauma registry data from a Level I trauma center between 2003 and 2008. Two proportional hazards regressions were used for analyses. The first predicted acquisition of UTI as a function of indwelling urinary catheter use, adjusting for age, diabetes, gender, and injury severity. The second predicted hospital mortality as a function of UTI, covarying for age, gender, chronic obstructive pulmonary disease, congestive heart failure, hypertension, diabetes, pneumonia, and injury severity.

RESULTS

After excluding patients who stayed in the hospital <3 days and those with a UTI on arrival, 5,736 patients were included in the study. Of these patients, 680 (11.9%) met criteria for a UTI, with 487 (71.6%) indwelling urinary catheter-related infections. Predictors of UTI included the interaction between age and gender (p = 0.0018), Injury Severity Score (p = 0.0021), and indwelling urinary catheter use (p < 0.001). The development of a UTI predicted the risk of in-hospital death as a patient's age increased (p = 0.002). Similar results were seen when only catheter-associated UTIs are included in the analysis.

CONCLUSIONS

Indwelling urinary catheter use is connected to the development of UTIs, and these infections are associated with a greater mortality as the age of a trauma patients increases.

摘要

背景

2008年10月,医疗保险和医疗补助计划停止支付与导尿管相关的尿路感染(UTI)的护理费用。尽管大多数临床医生都认为尿路感染有害,但几乎没有数据支持这一观点。

方法

这是一项对2003年至2008年间一级创伤中心创伤登记数据的回顾性研究。使用两个比例风险回归进行分析。第一个模型预测UTI的发生是留置导尿管使用情况的函数,并对年龄、糖尿病、性别和损伤严重程度进行了调整。第二个模型预测医院死亡率是UTI的函数,并对年龄、性别、慢性阻塞性肺疾病、充血性心力衰竭、高血压、糖尿病、肺炎和损伤严重程度进行了协变量分析。

结果

在排除住院时间<3天的患者和入院时即患有UTI的患者后,5736例患者被纳入研究。其中,680例(11.9%)符合UTI标准,487例(71.6%)为留置导尿管相关感染。UTI的预测因素包括年龄与性别的交互作用(p = 0.0018)、损伤严重程度评分(p = 0.0021)和留置导尿管的使用(p < 0.001)。随着患者年龄的增加,UTI的发生预示着住院死亡风险增加(p = 0.002)。当分析中仅包括与导尿管相关的UTI时,也得到了类似的结果。

结论

留置导尿管的使用与UTI的发生有关,并且随着创伤患者年龄的增加,这些感染与更高的死亡率相关。

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