鸡视网膜褪黑素受体再探讨：激动剂结合鸟嘌呤核苷酸的定位与调节
The chick retinal melatonin receptor revisited: localization and modulation of agonist binding with guanine nucleotides.
作者信息
Laitinen J T, Saavedra J M
机构信息
Section on Pharmacology, National Institute of Mental Health, Bethesda, MD 20892.
出版信息
Brain Res. 1990 Oct 1;528(2):349-52. doi: 10.1016/0006-8993(90)91681-6.
PMID:2176912
Abstract
The chick retinal melatonin receptor was localized to the inner plexiform layer using 2-125I-melatonin and in vitro autoradiographic techniques. This receptor was of high affinity (Kd 19.8 pM) and specificity and showed guanine nucleotide modulation of agonist binding. It thus behaves similarly to other recently characterized high affinity melatonin receptors.
摘要
利用2-125I-褪黑素和体外放射自显影技术，将鸡视网膜褪黑素受体定位于内网状层。该受体具有高亲和力（解离常数Kd为19.8皮摩尔）和特异性，并表现出激动剂结合的鸟嘌呤核苷酸调节作用。因此，它的行为与其他最近鉴定的高亲和力褪黑素受体相似。
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