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Hyposecretion of the Adrenal Androgen Dehydroepiandrosterone Sulfate (DHEA-S) in the Majority of the Alopecia Areata Patients: Is it a Primitive and Pathogenic Perturbation of Hypothalamic-Pituitary-Adrenal Axis?

作者信息

d'Ovidio Roberto, d'Ovidio Francesco Domenico

机构信息

National Coordinator, Trichology Group, Associazione Italiana Dermatologi Ambulatoriali (AIDA) - Day Hospital S.Camillo, Monopoli (Bari), Italy.

出版信息

Int J Trichology. 2011 Jan;3(1):43-4. doi: 10.4103/0974-7753.82130.

DOI:10.4103/0974-7753.82130
PMID:21769240
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3129128/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e43/3129128/542568d75e77/IJT-3-43-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e43/3129128/542568d75e77/IJT-3-43-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e43/3129128/542568d75e77/IJT-3-43-g002.jpg

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Hyposecretion of the Adrenal Androgen Dehydroepiandrosterone Sulfate (DHEA-S) in the Majority of the Alopecia Areata Patients: Is it a Primitive and Pathogenic Perturbation of Hypothalamic-Pituitary-Adrenal Axis?大多数斑秃患者肾上腺雄激素硫酸脱氢表雄酮（DHEA-S）分泌不足：这是下丘脑-垂体-肾上腺轴的原发性致病紊乱吗？
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本文引用的文献

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An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic?斑秃发病机制中的意外转折：NK 细胞具有保护作用，而 CD49b+T 细胞具有致病性？
Exp Dermatol. 2010 Aug;19(8):e347-9. doi: 10.1111/j.1600-0625.2010.01106.x.
2
Dehydroepiandrosterone as a regulator of immune cell function.脱氢表雄酮作为免疫细胞功能的调节剂。
J Steroid Biochem Mol Biol. 2010 May 31;120(2-3):127-36. doi: 10.1016/j.jsbmb.2009.12.016. Epub 2010 Jan 12.
3
Neuroendocrine and immunological correlates of chronic stress in 'strictly healthy' populations.
“严格健康”人群慢性应激的神经内分泌和免疫相关性。
Neuroimmunomodulation. 2010;17(1):9-18. doi: 10.1159/000243080. Epub 2009 Oct 5.
4
Prolactin levels in the patients with alopecia areata.
J Eur Acad Dermatol Venereol. 2009 Nov;23(11):1343-4. doi: 10.1111/j.1468-3083.2009.03222.x. Epub 2009 Mar 16.
5
Low serum levels of sex steroids are associated with disease characteristics in primary Sjogren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations.原发性干燥综合征患者血清中低水平的性激素与疾病特征相关；补充脱氢表雄酮可恢复其浓度。
J Clin Endocrinol Metab. 2009 Jun;94(6):2044-51. doi: 10.1210/jc.2009-0106. Epub 2009 Mar 24.
6
Thyroid autoimmunity in patients with alopecia areata.斑秃患者的甲状腺自身免疫
Acta Dermatovenerol Croat. 2008;16(3):123-5.
7
Defect of a subpopulation of natural killer immune cells in Graves' disease and Hashimoto's thyroiditis: normalizing effect of dehydroepiandrosterone sulfate.格雷夫斯病和桥本甲状腺炎中自然杀伤免疫细胞亚群的缺陷：硫酸脱氢表雄酮的归一化作用
Eur J Endocrinol. 2005 May;152(5):703-12. doi: 10.1530/eje.1.01906.
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Neural immune pathways and their connection to inflammatory diseases.神经免疫通路及其与炎症性疾病的联系。
Arthritis Res Ther. 2003;5(6):251-65. doi: 10.1186/ar1002. Epub 2003 Sep 23.
9
Psychosomatic factors in first-onset alopecia areata.首发斑秃中的身心因素。
Psychosomatics. 2003 Sep-Oct;44(5):374-81. doi: 10.1176/appi.psy.44.5.374.
10
[Pathogenesis of severe forms of alopecia areata].[重度斑秃的发病机制]
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