Nastainczyk W, Ludwig A, Hofmann F
Institut für Medizinische Biochemie, Medizinische Fakultät, Universität des Saarlandes, Homburg, Federal Republic of Germany.
Gen Physiol Biophys. 1990 Aug;9(4):321-9.
The dihydropyridine-sensitive calcium channel of the rabbit skeletal muscle is the first voltage-gated calcium channel which has been purified and biochemically characterized. The alpha 1-subunit, a 165 kDa protein, of the purified dihydropyridine receptor contains all regulatory sites of a L-type calcium channel and the calcium conducting unit. The purpose of this review is to summarize and discuss recent findings on the structure and possible function of the skeletal muscle calcium channel subunits.
兔骨骼肌中的二氢吡啶敏感钙通道是首个得到纯化并进行生化特性鉴定的电压门控钙通道。纯化后的二氢吡啶受体的α1亚基是一种165 kDa的蛋白质，它包含L型钙通道的所有调节位点以及钙传导单元。本综述的目的是总结和讨论骨骼肌钙通道亚基结构及可能功能的最新研究发现。
