Mohindra J, Subramoniam A, Seth P K
Developmental Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India.
Indian J Exp Biol. 1990 Jul;28(7):688-90.
Adult rats raised on 90% iron deficient diet for 6 weeks showed a decrease in the levels of brain phosphatidylinositol (60%), phosphatidylinositol 4-phosphate (25%) and phosphatidylinositol 4,5-bisphosphate (30%), the precursors for the second messengers, diacylglycerol and inositol phosphates. Rehabilitation to normal diet for 24 days was found to restore the levels to control values. The data suggests that iron deficiency could lead to alterations in the functions related to phosphoinositide-linked receptor system(s).
以缺铁90%的饮食饲养6周的成年大鼠，其脑磷脂酰肌醇（60%）、磷脂酰肌醇4-磷酸（25%）和磷脂酰肌醇4,5-二磷酸（30%）水平降低，这些都是第二信使二酰甘油和肌醇磷酸的前体。发现恢复正常饮食24天可使这些水平恢复到对照值。数据表明缺铁可能导致与磷酸肌醇连接受体系统相关的功能改变。
